A SIMPLE KEY FOR PKRRATING UNVEILED

The activated enzyme then more info phosphorylates its big substrate, the translational initiation element eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs into a conserved family of four protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in response to distinct stimuli12, triggering the built-i